IGF-1 receptor density begins declining after 68 weeks of continuous ligand exposure due to negative feedback mechanisms that downregulate receptor transcription extending cycles beyond this point produces diminishing returns where the same dose generates progressively weaker mTOR activation
Dev Biol 305(2):460469 Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC (2013) Structure of the human smoothened receptor bound to an antitumour agent
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